I’d be curious to know – In what do you carry your precious cargo? Are you happy with it? If not, why not? Is there another bag/pack/sack that you lust for?
I use a rolling hard plastic toolbox for the big stuff which I selected based on its dimensions to fit my car’s trunk perfectly, and a large crumpler for the expensive stuff. The toolbox can lock and I can chain it to something, although it’s not exactly a safe. I also have a large thinktank carry-on if I have to pack a lot of gear on a trip. I highly recommend thinktank products, if their other stuff is as awesome as that rolling carry-on bag.
Crumpler looks good and protects my gear, and isn’t horrible to carry unless it’s packed with glass. Comfortable strap, but can get unwieldy when packed full. But it carries a surprising amount of gear. I think you could actually get 3 cameras with 70-200 2.8 lenses and 3 flashes into it if you really tried, although that would be painful to carry. I think I have the $7M Home.